Knowledge Centre
NAD+ Energy & Longevity
The cellular coenzyme, explained.
NAD+ is the coenzyme cells use for energy and DNA repair, and it falls with age. Here is why it sits at the centre of longevity research and how it is studied.
NAD+ (nicotinamide adenine dinucleotide) is a coenzyme found in every living cell. Technically it is grouped with peptides in the research catalogue, but it is really a metabolic cofactor — one the body cannot run without.
Its two headline jobs: shuttling energy inside the mitochondria, and acting as fuel for the enzymes that repair DNA and regulate ageing.
- Cellular energy — NAD+ is central to how mitochondria turn food into usable energy.
- DNA repair — repair enzymes (PARPs) consume NAD+ as they work.
- Sirtuins — the “longevity enzymes” depend on NAD+ to function.
- Neuroprotection — a growing area of NAD+ research.
Because NAD+ declines markedly with age, restoring it is the central idea behind NAD+ research — the thinking being that you give cells back a resource they are running short of.
NAD+ is reconstituted with bacteriostatic water and refrigerated once mixed. It is often studied at higher volumes and slower administration than smaller peptides; our reconstitution and dosage calculator cover the maths.
Is NAD+ a peptide?
Technically it is a coenzyme rather than a peptide, but it is grouped with research peptides because of how it is supplied and studied.
Why does NAD+ research focus on ageing?
NAD+ levels fall with age, and it fuels both energy production and the DNA-repair and sirtuin systems tied to longevity.